FivepHusion Announces Strategic Collaboration with Treehill Partners and Syneos Wellness

Supporting FivepHusion’s International Improvement and Commercialization Technique

SYDNEY, May perhaps 26, 2023 /PRNewswire/ — FivepHusion, an sophisticated clinical-stage biotechnology firm, right now announced its collaboration with Treehill Partners, a New York-primarily based strategic and monetary advisory firm specializing in healthcare business transactions, and Syneos Health® (Nasdaq: SYNH), a major totally integrated biopharmaceutical options organization, to create and bring a novel, enhanced chemotherapeutic solution to marketplace.

Treehill Partners will help FivepHusion with integrated business enterprise improvement, operational, strategic and transactional knowledge. Syneos Wellness will help FivepHusion’s integrated clinical improvement and commercialization capabilities. This collaboration is developed to strategically and optimally progress improvement and commercialization of FivepHusion’s enhanced chemotherapeutic formulation Deflexifol™ in worldwide markets.

“This is a pretty thrilling time for FivepHusion. We are at a important stage in our development approach. By collaborating with Treehill Partners and Syneos Wellness, we think we are positioned to effectively bring our improvement function on Deflexifol™ to worldwide markets, such as in the US, Europe and Asia,” mentioned Dr. Christian Toouli, CEO &amp Managing Director, FivepHusion. “This collaboration represents a special operating model to the business. Via the combined strength and competency of 3 business leaders, we intend to maximize our progress on the improvement of Deflexifol™ and speedily bring revolutionary oncology medicines to sufferers in have to have.”

“We’re excited to collaborate with FivepHusion and Treehill Partners to aid bring Deflexifol™ to sufferers,” mentioned Christian Tucat, Chief Organization Officer, Syneos Wellness. “Leveraging our deep therapeutic and worldwide knowledge, Syneos Wellness is pleased to contribute to accelerating the clinical improvement and commercialization of this significant new therapy.”

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“This collaboration represents a new model of integrated solutions across disciplines, developed to enable US and non-US emerging players to play a essential part on the worldwide stage, and we’re proud to function alongside FivepHusion and Syneos Wellness,” mentioned Ali Pashazadeh, Companion &amp Co-founder, Treehill Partners. “By merging the scientific prowess of our consumers with the clinical and industrial knowledge of Syneos Wellness and Treehill’s healthcare advisory and execution capabilities, we are offering a special ecosystem developed to aid firms to flourish regardless of the existing difficult marketplace atmosphere.”

About FivepHusion

FivepHusion (www.fivephusion.com) is an sophisticated clinical-stage, globally focused biotechnology firm whose goal is to optimize chemotherapy to enhance patient therapy outcomes and high-quality of life.

FivepHusion is building Deflexifol™, a proprietary, novel, and optimized physiological pH formulation to co-administer the chemotherapeutic agent five-fluorouracil (five-FU) and its biomodulator leucovorin (LV), a drug that enhances five-FU anti-cancer activity. These drugs are usually utilised globally to treat many strong tumors such as colorectal, pancreatic, gastric and breast cancers. On the other hand, due to their chemical incompatibility, existing formulations of five-FU and LV endure from limitations in their security, tolerability, effectiveness and pharmacological compatibility. These disadvantages contribute to restricted therapy response prices, unpleasant side effects and toxicities, and a decreased high-quality of life seasoned by cancer sufferers. Deflexifol™ has been developed to address these limitations via co-administration of the two agents with clinically demonstrated improvements in security and tolerability and the prospective to present superior anti-tumor efficacy, improved high-quality of life, and all round enhanced clinical advantage for cancer sufferers.

FivepHusion is building Deflexifol™ through the FDA 505(b)(two) and EMA Short article 10b regulatory pathways as a bioequivalent, chemotherapy replacement of sub-optimal typical of care formulations of five-FU and LV for the therapy of metastatic colorectal cancer, and other tumors with a projected worldwide incidence of higher than six million sufferers. Deflexifol™ is also becoming created as a new therapy for cancers with higher unmet health-related have to have, such as pediatric ependymoma a uncommon and deadly brain cancer which afflicts pretty young kids.

Deflexifol™ is a trademark of FivepHusion.

About Syneos Wellness

Syneos Health® (Nasdaq: SYNH) is a major totally integrated biopharmaceutical options organization constructed to accelerate consumer accomplishment.  Syneos translates special clinical, health-related affairs and industrial insights into outcomes to address contemporary marketplace realities.

Syneos brings with each other a talented group of experts, who function across extra than 110 nations, with a deep understanding of patient and doctor behaviors and marketplace dynamics. With each other Syneos shares insights, makes use of the newest technologies and applies sophisticated business enterprise practices to speed customers’ delivery of significant therapies to sufferers.

Syneos Wellness supports a diverse, equitable and inclusive culture that cares for colleagues, clients, sufferers, communities and the atmosphere.

To study extra about how Syneos are Shortening the distance from lab to life®, check out syneoshealth.com or subscribe to our podcast.

About Treehill Partners

Treehill was founded in 2014 and is led by companion and co-founder Ali Pashazadeh, who previously headed Blackstone’s healthcare advisory group and UBS’ European biotech coverage.

Treehill supports consumers in the healthcare business all through the asset lifecycle, from acquire-side acquisition and investment more than worth develop and development to sell-side disposal and divestment. Essential places of concentrate are the identifying and executing of worth inventive transactions and their knitting into profitable corporate evolution approaches.

In delivering its suggestions, the firm employs a multidisciplinary senior group with impeccable pedigree that comprises health-related physicians/ MDs, scientists/ PhDs, CEOs of biotechs, senior executives from significant pharma, and seasoned approach consultants and investment bankers. Solutions supplied are centered about the “principal mentality” of the group, delivering actionable strategic and transaction suggestions that matters to CEOs, senior leadership, their stakeholders and investors.

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