Cartherics and TiCARos collaborate to lead advancement of CLIP-CAR technology

Collaboration between Cartherics and TiCARos to Develop CLIP-CAR Constructs for Assessing NK Cell Function in Cancer Therapy

Cartherics, a leading company in the field of cancer therapy, has announced a collaboration with TiCARos to develop CLIP-CAR constructs for assessing the function of NK cells. This collaboration will incorporate TiCARos’ unique CLIP-CAR approach into Cartherics’ allogeneic NK cell platform.

TiCARos is a company specializing in developing CAR-T cell products for the treatment of solid and blood cancers using its CLIP-CAR approach. This approach modifies the CAR structure to stabilize the immune synapse between immune cells and target tumor cells, resulting in improved efficacy in models.

Cartherics’ CEO, Professor Alan Trounson, believes that combining TiCARos’ CLIP-CAR technology with Cartherics’ allogeneic NK cell platform has the potential to enhance the effectiveness of cancer therapies. By collaborating with innovative companies like TiCARos, Cartherics aims to build a leading portfolio of therapeutic products for cancer treatment.

The collaboration between the two companies will focus on developing a CAR-NK product targeting tissue factor (TF) for triple negative breast cancer and other challenging cancers. Each company has nominated a specific tumor antigen to target with the CARs, with Cartherics focusing on TF and TiCARos targeting CD19. The goal of this collaboration is to accelerate pipeline programs and expand the use of TiCARos’ technology beyond autologous cell therapies. If the research collaboration yields positive results, Cartherics and TiCARos will negotiate a development and commercialization agreement for their CAR-NK therapeutic approach.

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